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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2002 1
2003 1
2004 5
2005 1
2006 2
2007 7
2008 10
2009 19
2010 18
2011 13
2012 18
2013 21
2014 22
2015 27
2016 30
2017 25
2018 13
2019 19
2020 17
2021 20
2022 11
2023 8
2024 3

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259 results

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Page 1
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.Abbreviations: AKT1S1: AKT1 substrate 1; AMBRA1: autophagy and beclin 1 regula …
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting …
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Devis-Jauregui L, et al. Autophagy. 2021 May;17(5):1077-1095. doi: 10.1080/15548627.2020.1752548. Epub 2020 May 13. Autophagy. 2021. PMID: 32401642 Free PMC article. Review.
Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.Abbreviations: 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; …
Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.Abbreviations: 3-M …
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X, Xiao G, Wang M. Yang H, et al. Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21. Autophagy. 2020. PMID: 31007149 Free PMC article.
Thus, inhibition of MTORC1 provides a novel therapeutic strategy for prevention and treatment of OA.Abbreviations : ACTB: actin beta; ATF6: activating transcription factor 6; BECN1: beclin 1; BFL: bafilomycin A(1); CASP12: caspase 12; CASP3: caspase 3; DAPI: 4',6-diamidino-2-phen …
Thus, inhibition of MTORC1 provides a novel therapeutic strategy for prevention and treatment of OA.Abbreviations : ACTB: actin beta; ATF6: …
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB. Ming SL, et al. Autophagy. 2022 Aug;18(8):1801-1821. doi: 10.1080/15548627.2021.2002101. Epub 2021 Nov 25. Autophagy. 2022. PMID: 34822318 Free PMC article.
Our results suggested that USP14 was a potential therapeutic target to treat alphaherpesvirus-induced infectious diseases.Abbreviations ATF4: activating transcription factor 4; ATF6: activating transcription factor 6; ATG5: autophagy related 5; ATG12: autophagy related 12; CCK-8: …
Our results suggested that USP14 was a potential therapeutic target to treat alphaherpesvirus-induced infectious diseases.Abbreviations ATF4 …
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death.
Wan H, Wang Q, Chen X, Zeng Q, Shao Y, Fang H, Liao X, Li HS, Liu MG, Xu TL, Diao M, Li D, Meng B, Tang B, Zhang Z, Liao L. Wan H, et al. Autophagy. 2020 Mar;16(3):531-547. doi: 10.1080/15548627.2019.1630224. Epub 2019 Jun 23. Autophagy. 2020. PMID: 31204559 Free PMC article.
Thus, the loss of WDR45 cripples macroautophagy machinery in neurons and leads to impairment in organelle autophagy, which provides a mechanistic understanding of cause of BPAN and a potential therapeutic strategy to treat this genetic disorder.Abbreviations: 7-ADD: 7-aminoactino …
Thus, the loss of WDR45 cripples macroautophagy machinery in neurons and leads to impairment in organelle autophagy, which provides a mechan …
Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension.
Lemay SE, Bonnet S, Potus F. Lemay SE, et al. Clin Sci (Lond). 2022 Jan 14;136(1):163-166. doi: 10.1042/CS20211095. Clin Sci (Lond). 2022. PMID: 35005770
Xbp1s-Ddit3 is involved in the regulation of endoplasmic reticulum stress but is also associated with DNA damage repair machinery. Pathologic DNA damage repair mechanisms have emerged as critical determinants of pulmonary hypertension development. We discuss the potential …
Xbp1s-Ddit3 is involved in the regulation of endoplasmic reticulum stress but is also associated with DNA damage repair machinery. Pa …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X. Zheng ZG, et al. Autophagy. 2021 Jul;17(7):1592-1613. doi: 10.1080/15548627.2020.1757955. Epub 2020 May 20. Autophagy. 2021. PMID: 32432943 Free PMC article.
Our study demonstrated that the inhibition of SCAP through the SMAILD pathway could be employed as a useful therapeutic strategy for treating metabolic diseases.Abbreviation: 25-OHD: 25-hydroxyvitamin D; 3-MA: 3-methyladenine; ABCG5: ATP binding cassette subfamily G member 5; ABC …
Our study demonstrated that the inhibition of SCAP through the SMAILD pathway could be employed as a useful therapeutic strategy for treatin …
Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis.
Abbonante V, Malara A, Chrisam M, Metti S, Soprano P, Semplicini C, Bello L, Bozzi V, Battiston M, Pecci A, Pegoraro E, De Marco L, Braghetta P, Bonaldo P, Balduini A. Abbonante V, et al. Autophagy. 2023 Mar;19(3):984-999. doi: 10.1080/15548627.2022.2100105. Epub 2022 Jul 20. Autophagy. 2023. PMID: 35857791 Free PMC article.
The unfolded protein response is activated in col6a1(-/-) megakaryocytes, as evidenced by the upregulation of molecular chaperones, by the increased splicing of Xbp1 mRNA and by the higher level of the pro-apoptotic regulator DDIT3/CHOP. ...These data demonstrate th …
The unfolded protein response is activated in col6a1(-/-) megakaryocytes, as evidenced by the upregulation of molecular chaperones, by the i …
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C. El Manaa W, et al. Autophagy. 2021 Dec;17(12):4363-4385. doi: 10.1080/15548627.2021.1917129. Epub 2021 May 24. Autophagy. 2021. PMID: 34030589 Free PMC article.
The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional splicing by the nuclease ERN1/IREalpha thereby yielding XBP1s, whereas PINK1 is a kinas …
The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription …
Endoplasmic reticulum stress in bipolar disorder? - BiP and CHOP gene expression- and XBP1 splicing analysis in peripheral blood.
Bengesser SA, Reininghaus EZ, Dalkner N, Birner A, Hohenberger H, Queissner R, Fellendorf F, Platzer M, Pilz R, Hamm C, Rieger A, Kapfhammer HP, Mangge H, Reininghaus B, Meier-Allard N, Stracke A, Fuchs R, Holasek S. Bengesser SA, et al. Psychoneuroendocrinology. 2018 Sep;95:113-119. doi: 10.1016/j.psyneuen.2018.05.029. Epub 2018 May 21. Psychoneuroendocrinology. 2018. PMID: 29843019
Spliced XBP1 (F(1/126) = 5.848, p = 0.017, Partial eta(2) = 0.044) and the ratio spliced XBP1/ unspliced XBP1 did not differ between BD and controls (F(1/126) = 0.599, p = 0.441, Partial eta(2) = 0.005). ...Nevertheless, XBP1 splicing itself did not di …
Spliced XBP1 (F(1/126) = 5.848, p = 0.017, Partial eta(2) = 0.044) and the ratio spliced XBP1/ unspliced XBP1 did not d …
259 results